关键词:
Continuous cortisol monitoring
Computational chemistry
Organic electrochemical transistors
Wearable biosensor
Molecularly imprinted polymer
Printing electronics
摘要:
Continuous cortisol monitoring(CCM)is essential for stress management,providing physiological insights into psychology and physical ***,promising platform for CCM urges the design of effective biorecognition moieties and the skin integration of sophisticated ***,we present a computationally-assisted wearable system for CCM(CWSCCM)that leverages cutting-edge interdisciplinary technologies of in-situ regenerative molecularly imprinted polymers(MIP),signal amplifier organic electrochemical transistor(OECT),iontophoresis-based sweat induction,and microfluidic sweat *** highly integrated system incorporated with OECT biosensor enables in-situ MIP regeneration,and offers continuous approach for cortisol monitoring,with an ultra-low limit of detection of0.36 nmol/*** validated the capability of the CWSCCM for long-term cortisol circadian rhythm monitoring in human participants,which shows superior sensitivity,selectivity,and continuous monitoring *** conclusion,we demonstrated how computational chemistry and OECT technology can extend the capabilities of current wearable CCM,which could potentially advance closed-loop therapeutics applications.